The Edit · Founder Insights
If a GLP-1 is already doing the fat loss, do you still need a coach? Yes, more than ever: a quarter to two-fifths of the weight lost is muscle.

If you are losing weight on Ozempic or another GLP-1, you need a coach more than you did before you started, not less. The medication does the fat loss, which is exactly why the question comes up: if the drug is already shrinking you, what is a trainer for? The answer is the part the drug does not handle. Between a quarter and two-fifths of the weight you lose on a GLP-1 is muscle, not fat, and the only thing that holds onto it is resistance training and enough protein. That is the half of the equation a prescription cannot fill.
TL;DR
- Roughly 25 to 39% of the weight lost on a GLP-1 is muscle, not fat, so the drug alone leaves your body composition worse than it looks on the scale.
- The semaglutide trial STEP 1 and the tirzepatide trial SURMOUNT-1 bracket that range; in SURMOUNT-1 fat loss was about three times lean-mass loss.
- In a randomised trial, adding exercise to a GLP-1 roughly doubled the drop in body-fat percentage and protected lean mass versus the drug alone.
- A coach delivers the three things the drug cannot: progressive load, a protein target, and a body-composition re-test to prove you lost fat and kept muscle.
- After 40, muscle lost on a GLP-1 compounds the muscle you are already losing to age, which is why a coach matters more, not less.
What the drug does and does not do
A GLP-1 receptor agonist like semaglutide, sold as Ozempic and Wegovy, suppresses appetite and produces weight loss that no diet reliably matches. That is what it is for, and it does it well. What it does not do is decide how much of that weight is fat and how much is muscle. The drug removes weight; it does not protect lean tissue on your behalf.
That distinction is the whole reason a coach still belongs in the picture. Losing fat improves the numbers on a health-screening report. Losing muscle quietly erodes the strength, stability and metabolic capacity those numbers are meant to protect. The scale moving down tells you nothing about which tissue left. A body-composition measurement does, and a coaching plan changes the answer. We cover the underlying mechanism in full in our explainer on keeping muscle while you lose fat on a GLP-1; this piece is about the decision that follows from it.
The 25 to 39% muscle-loss number
Here is the figure that reframes the question. A 2024 review in the Lancet Diabetes and Endocrinology pooled the major trials and found that 25 to 39% of the total weight lost on medically induced weight loss was fat-free mass, which is mostly muscle, rather than fat. In other words, for every 10 kilograms a GLP-1 takes off, somewhere between two-and-a-half and four of them can be muscle leaving your body.
The two landmark drug trials bracket that range. In STEP 1, once-weekly semaglutide produced a mean body-weight reduction of 14.9% over 68 weeks, against 2.4% on placebo, and a meaningful share of that loss was lean mass. At the upper end, SURMOUNT-1 tested tirzepatide and reached up to around 20.9% body-weight reduction over 72 weeks, with fat-mass loss running roughly three times lean-mass loss, about 33.9% fat against 10.9% lean. Different drugs, different totals, but the same pattern: the muscle goes too, and nothing in the prescription stops it.
The drug decides how much weight you lose. You decide how much of it is muscle.
Why the drug plus a coach beats the drug alone
This is where the evidence answers the question directly. In a randomised trial in the New England Journal of Medicine, people who had already lost weight were assigned to a structured exercise programme, an earlier-generation GLP-1, both together, or neither. The group that combined exercise with the drug came out best: they roughly doubled the reduction in body-fat percentage compared with either intervention on its own, and they preserved lean mass that the drug-alone group did not.
The trial used liraglutide, an earlier GLP-1 rather than Ozempic or Wegovy specifically, but the principle it established is the one that matters for the decision in front of you. The drug by itself improves your weight. The drug plus the training improves your body. The combination, not the medication alone, is what produces the lean, strong physiology people think they are buying when they start a GLP-1. A prescription gets you halfway. The coaching is the other half.
What coaching actually delivers on a GLP-1
Strip away the marketing and a coach on a GLP-1 delivers three concrete things. The first is progressive resistance load: meaningful weight, lifted two to three times a week and increased over time, which is the signal that tells your body to hold onto the muscle it would otherwise shed in a deficit. Walking and light movement do not send that signal; loaded training does.
The second is a protein target, around 1.2 grams per kilogram of body weight per day or more, eaten deliberately and first at each meal. This is genuinely harder on a GLP-1, because the drug suppresses appetite, so hitting the target takes a plan rather than an intention. The third is measurement: a body-composition baseline before the weight moves and a re-test a few months in, so you can prove the scale dropped fat while the muscle held, instead of finding out a year later that it did not. That is exactly how we coach clients training on a GLP-1, and it is the difference between a smaller version of an unwell body and a genuinely recomposed one after 40.
Why this matters more after 40
If you are in your 40s or beyond, you are already losing muscle to age, slowly, every year, whether or not you notice. A GLP-1 layered on top accelerates that loss at the stage of life when muscle is hardest to rebuild. The muscle you give away on the drug now is muscle you will be trying to claw back into your 50s, 60s and the decades after, against a tide that is already running the wrong way.
That is the healthspan argument for keeping a coach rather than dropping one. The goal is not to look leaner for a photo; it is to arrive in your next decade strong, steady and independent, with the muscle that carries you there intact. The fat loss the drug gives you is real and worth having. The muscle loss that rides along with it is the price, and a coach is how you avoid paying it. For clients over 50 that is the entire game, which is why we treat training over 50 as a muscle-preservation project first.
The decision
So, do you still need a trainer if you are on Ozempic? Yes, and the medication is the reason, not the excuse to skip it. The drug has taken on the part of weight loss that used to be the hard part, the appetite and the deficit. What remains is the part it was never going to do: keeping the muscle, building the strength, and turning a lighter body into a more capable one.
The starting point is knowing what you are actually working with. Every client begins with the Catalyst Healthspan Assessment, which measures body composition, cardiorespiratory fitness, stability and strength, so there is a real baseline before the weight moves. We are not a medical provider and do not prescribe; that conversation belongs with your doctor. What we add is the coaching that makes sure the weight you lose on the drug is fat, and the muscle that carries you forward stays where it belongs.
Frequently asked questions
Q. Do I still need a personal trainer if I am taking Ozempic?
Yes, arguably more than before. A GLP-1 handles the appetite and the deficit, but 25 to 39% of the weight you lose on it is muscle rather than fat, according to a 2024 Lancet Diabetes and Endocrinology review. Only resistance training and adequate protein preserve that muscle, and that is precisely what a coach delivers and a prescription does not.
Q. Does Ozempic make you lose muscle as well as fat?
Yes. Across the major trials, roughly a quarter to two-fifths of the total weight lost on a GLP-1 is lean mass, not fat. In the SURMOUNT-1 tirzepatide trial, fat loss ran about three times lean-mass loss. The drug removes weight efficiently but does not preferentially spare muscle, so without strength training a meaningful share of what you lose is muscle.
Q. Is strength training or cardio better while on a GLP-1?
Strength training is the priority. Resistance training is the signal that tells your body to keep muscle during weight loss, which cardio alone does not provide. In a randomised trial, combining structured exercise with a GLP-1 roughly doubled the drop in body-fat percentage and protected lean mass versus the drug alone. Two to three loaded sessions a week is the foundation, with cardio added on top.
Q. How much protein should I eat on Ozempic in Singapore?
Aim for around 1.2 grams of protein per kilogram of body weight per day or more, spread across meals and eaten first. This is harder on a GLP-1 because the medication suppresses appetite, so protein has to be planned deliberately rather than left to whatever you feel like eating.
Q. Can a trainer help me keep muscle on a GLP-1 if I am over 50?
Yes, and it matters more after 50, not less, because muscle is harder to rebuild with age. The approach is the same: measure a body-composition baseline before the weight moves, train with real load two to three times a week, hit your protein target, and re-test to confirm you are losing fat and holding muscle.
Citations
Prado, C. M., Phillips, S. M., Gonzalez, M. C., & Heymsfield, S. B. (2024). Muscle matters: the effects of medically induced weight loss on skeletal muscle. The Lancet Diabetes & Endocrinology, 12(11), 785-787. pubmed.ncbi.nlm.nih.gov
Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1). New England Journal of Medicine, 384(11), 989-1002. pubmed.ncbi.nlm.nih.gov
Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1). New England Journal of Medicine, 387(3), 205-216. pubmed.ncbi.nlm.nih.gov
Lundgren, J. R., Janus, C., Jensen, S. B. K., Juhl, C. R., Torekov, S. S., et al. (2021). Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined. New England Journal of Medicine, 384(18), 1719-1730. pubmed.ncbi.nlm.nih.gov

